This paper examines trends in the productivity of the pharmaceutical sector over the past three decades. Motivated by Ricardo’s insight regarding demand-driven productivity in settings of scarce resources, we examine the industry’s aggregate R&D production function. Using exogenous demand shocks to instrument investments, we find that demand growth explains roughly half of R&D growth and amongst this demand-induced R&D, the industry’s returns to scale have been very stable while total factor productivity has declined significantly. Suggestive evidence based on these estimates is in line with Ricardo’s prediction that productivity and rents are endogenous to demand.

More on this topic

BFI Working Paper·Aug 4, 2026

Two Selection Problems, One Bias Term: Experimental Sign-Up Is Treatment Choice in Disguise

John List
Topics: Uncategorized
BFI Working Paper·Jun 23, 2026

Misleading Estimates from Nonlinear Models with a Binary Outcome

Brian Curran, Bruce Meyer, and Derek Wu
Topics: Uncategorized
BFI Working Paper·Jun 15, 2026

Don’t Give Up on Lab Experiments: Why the Field Still Needs the Lab

John List
Topics: Uncategorized